SilymarinAdvanced®
$49.99
SilymarinAdvanced® Liver Health Supplement
- Milk Thistle Liver Support with S-Adenosylmethionine
(Same) & Silybin - Liver Detox
SilymarinAdvanced®: Comprehensive Liver Support for Large Dogs
Support your large dog’s liver health with SilymarinAdvanced®, a premium dog liver support supplement designed to detoxify, protect, and restore. Each tablet features a powerful blend of 425 mg of S-Adenosylmethionine (SAMe) and 35 mg of Silybin, derived from Milk Thistle, for a dual-action approach to liver health.
SAMe plays a crucial role in liver metabolism, helping remove toxins and regenerate cells. Silybin, a key compound in Milk Thistle, delivers potent anti-inflammatory and anti-fibrotic benefits, protecting the liver from damage and aiding in the recovery process. Beyond liver health, SilymarinAdvanced® promotes sharp, alert brain function in dogs. SAMe is known to improve cognitive performance, making this supplement ideal for pets who need both liver and brain support.
Developed with veterinarians and nutritional experts, SilymarinAdvanced® is made without chemical coatings, artificial colors, or harmful additives. This uncoated liver supplement for dogs preserves 100% bioavailability, ensuring your pet receives the full benefits of its active ingredients. With just one simple tablet a day, you can help maintain your large dog’s liver function, reduce inflammation, and support overall well-being.
SilymarinAdvanced® combines the best of nature and science to deliver a superior liver health solution for large dogs. Choose the supplement that offers powerful liver detoxification, inflammation reduction, and cognitive enhancement — all in a safe, natural, and easy-to-give formula.
SilymarinAdvanced® combines S-Adenosylmethionine (SAMe), Silybin (Milk Thistle), and Phosphatidylcholine to provide a comprehensive solution for your pet’s health. Designed for both dogs and cats, this unique formula supports:
For pets with these specific concerns, incorporating SilymarinAdvanced® into their daily routine offers targeted, scientifically backed support.
Each tablet contains:
Crafted to enhance your pet’s liver health, this milk thistle liver supplement for dogs features a potent combination of 425 mg of SAMe and 35 mg of Silybin. Together, these ingredients work to detoxify and repair the liver, maintaining optimal liver function and ensuring your furry friend stays healthy and happy.
Enriched with powerful anti-inflammatory flavonoids from milk thistle, this liver supplement helps eliminate harmful toxins and supports smooth liver function. By providing gentle yet effective detox support, it keeps your pet’s liver clean and thriving, promoting long-term health and vitality.
In addition to liver support, this formula includes SAMe, which is well-known for boosting cognitive function. The supplement helps your dog stay mentally sharp, alert, and vibrant, making it a valuable choice for pets of all ages, especially seniors.
This gluten-free, non-GMO dog supplement is free from chemical coatings, artificial colors, flavors, magnesium stearate, and titanium dioxide. With a pure and natural formulation, you can trust it to provide safe, effective care for your pet’s liver and overall health.
Developed by veterinary and nutritional experts, this SAMe and milk thistle liver supplement is designed for ease and reliability. Just one uncoated tablet per day delivers the targeted liver support your dog needs, making it a trusted and convenient solution for long-term health and recovery.
Tablets can be split, broken or swallowed whole. Tablets can also be crushed and sprinkled over food. Tablets can be given with meals or on an empty stomach. Tablets contain natural ingredients: Aspect and color may change over time; this does not affect the tablet’s effectiveness or the bioavailability of the active ingredients. Once opened, preferably use within 6 months.
1 tablet a day
2 tablets a day (or 1 tablet twice daily)
3 tablets a day
We use only the best, ensuring every supplement meets the highest quality standards.
Freshness and potency are guaranteed by producing in small, consistent batches throughout the year.
Each product is backed by the latest research to support optimal pet health.
Premium care for your pets without the premium price tag.
The SilymarinAdvanced® tablet is an innovative, uncoated formulation that combines SAMe and Silybin to support liver health in cats and dogs. Unlike traditional coated tablets, it contains no dyes or harmful chemicals, ensuring your pet receives 100% of the ingredients' bioavailability. Its uncoated design eliminates unnecessary additives while preserving the potency of its active compounds throughout its shelf life.
Tablet coatings are often used to mask natural ingredient colors and may include dyes or chemicals. We, at MedsMeHappy, feel that these additives are unnecessary and can interfere with treatments aimed at healing vital organs, like the liver. We therefore avoid coatings to ensure our supplements are safe, natural, and effective.
At MedsMeHappy, we prioritize both health and affordability. SilymarinAdvanced® offers premium SAMe and Silybin liver support starting at less than 56¢ per tablet per day, making high-quality liver care accessible for every pet parent.
The liver is a vital organ that plays a central role in digestion, metabolism, hormone synthesis, detoxification, and immune response. Keeping the liver healthy is critical to your pet’s overall well-being, especially since it can be affected by medications, chemicals, infections, and autoimmune conditions.
Liver diseases can arise from various causes and may include:
These conditions require early detection and proper care to maintain your pet’s health.
Common symptoms include:
If you notice these signs, consult your veterinarian promptly.
Silybin, derived from milk thistle (Silybum Marianum), is a potent compound with anti-inflammatory and liver-protective properties. Silybin is part of the Silymarin complex, which includes flavonoids that reduce liver inflammation and support detoxification. It is particularly effective in combating liver damage caused by toxins, medications, or infections.
SilymarinAdvanced® combines SAMe and Silybin, two powerful compounds that:
S-Adenosylmethionine (SAMe) is a naturally occurring molecule in your pet’s body that supports:
Supplementing SAMe helps restore these vital functions, especially in aging pets.
SilymarinAdvanced® stands out because it:
Yes! Research highlights their effectiveness:
Yes, SilymarinAdvanced® is generally safe to administer alongside most medications. However, consult your veterinarian to ensure compatibility with your pet’s specific treatment plan.
Veterinarians trust SilymarinAdvanced® for its scientifically proven formulation, human-grade ingredients, and ability to address liver health in cats and dogs effectively. It provides a reliable option for pets with liver conditions or those needing ongoing support.
This product has kept our dog's pancreatitis in check for many years. She is a mini dachshund and she is over 17 years old, ans still going strong.
I bought this product based on the reviews. It works as well as Denamarin but for a better price. My little doxie has liver disease and needs to be on this long term. So happy it’s helping him. I love the fact I can buy a 90 day supply. Thanks medsme happy. Very pleased with this product.
Hello, I started my furbaby on the milk thistle June 4th 2025 because her liver numbers are still high. I do have to put it in little plain yogurt or plain pumpkin so she will swallow it you can mix with food and I do like that option. I am excited about seeing her numbers next visit. She is fine and acting herself even after taking this product. My veterinarian did recommend it as well. I love the fact this company weights it out for the animals. Thanks Medsmehappy for doing the math
Very happy to find a generically alternative to Denamarain
Great price. Approved by my vet as a perfectly acceptable substitute for Denamarin Advanced. Labs yet to be drawn, but due May 16th. Fingers crossed. Would absolutely recommend and will buy again assuming positive results.
A lot cheaper than Denamarin and the same ingredients
We have had an 11 year old dog with an enlarged liver on Silymarin for about 8 months. His liver values were off the chart, discovered accidentally since he seems to feel ok. After six months his values came down just a little bit. We just had a second dog start on Silymarin since her liver values were somewhat elevated. We have no reason to believe there is any problem with the product and are satisfied. Fortunately, it is somewhat less expensive than Denamarin.
Our girl's liver values have greatly improved on silymarin. The Vet we had been going to, at the time, gave the name of an alternate med to Denamarin, but was just as costly because you had to give 2 pills a day. I looked at the ingred. and did some research online and found your product. In the mean time, I changed Vets and showed her the bottle and she said "let's give it a try". We are both happy with the results. I am glad I can get a 90 day supply directly from you and save.
My 5# Yorkie was diagnosed about 3 years ago with Liver Shunts and the prognosis was not very positive without major surgery and even then it looked bleak. We chose to forgo the expensive and not so good of an outcome and for us it was a good decision. She is going great with this product and her unusual diet that we are so grateful.
Labs are in and silymarin advanced did help bring my Malinois's liver values back into range. An excellent Denamarin substitute. Thank you so much for having this product and a more reasonable price point. Signing up for autoship today!